Endocrine Abstracts

A 72 year old gentleman with an eight month history of chronic, episodic diarrhoea had been investigated as an out-patient. Colonoscopy and biopsies, barium meal and follow-through, coeliac screen and thyroid function tests were all normal. He subsequently presented with an acute deterioration in diarrhoea, and severe hypokalaemia, acute renal failure and a profound metabolic acidosis. Haemofiltration and aggressive fluid management were required to compensate for gastro-intes...

A 51 year old woman was referred for investigation of goitre. The patient described weight loss, sweating and hot flushes for 3 years. A bilateral salpingo-oophorectomy had been performed 14 years prior to presentation but the patient had been off HRT for 12 years.On examination the patient was thin, nervous and sweaty with a sinus tachycardia and a smooth goitre, but no signs of thyroid eye disease.Thyroid hormone levels were elev...

The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...